pll Antibody

Code CSB-PA966458XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) pll Polyclonal antibody
Uniprot No.
Target Names
pll
Alternative Names
pll antibody; CG5974Serine/threonine-protein kinase pelle antibody; EC 2.7.11.1 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) pll protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll.
Gene References into Functions
  1. The IRAK homolog Pelle is the functional counterpart of IkappaB kinase in the Drosophila Toll pathway. PMID: 24086459
  2. an anteroposterior gradient of Pelle kinase activity is sufficient to generate all known Toll-Dorsal patterning thresholds of gene expression PMID: 12091311
  3. Cosolvent-induced transformation of the death domain tertiary structure PMID: 12177432
  4. NMR analysis of the isolated Pelle death domain PMID: 16004997
Subcellular Location
Cell membrane. Cytoplasm. Note=Associates with the plasma membrane during interphase syncytial blastoderm embryos, more specifically at the membrane invaginations around the nuclei.
Protein Families
Protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
Database Links

KEGG: dme:Dmel_CG5974

STRING: 7227.FBpp0084549

UniGene: Dm.2022

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