Kremen1 Antibody

Code CSB-PA860404XA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Kremen1 Polyclonal antibody
Uniprot No.
Target Names
Kremen1
Alternative Names
Kremen1 antibody; Kremen antibody; Kremen protein 1 antibody; Dickkopf receptor antibody; Kringle domain-containing transmembrane protein 1 antibody; Kringle-containing protein marking the eye and the nose antibody
Raised in
Rabbit
Species Reactivity
Mus musculus (Mouse)
Immunogen
Recombinant Mus musculus (Mouse) Kremen1 protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
Gene References into Functions
  1. Kremen1 is expressed in prosensory cells during cochlear developme PMID: 27550540
  2. Dickkopf1 receptor Kremen1 is a bona fide dependence receptor, triggering cell death unless bound to its ligand. PMID: 26206087
  3. Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 binding PMID: 26206087
  4. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling PMID: 12050670
  5. Dkk1 and Kremen1 play roles in blastocyst activation and uterine receptivity during the window of implantation. PMID: 18068158
  6. Kremen may not be essential for Dkk1-mediated Wnt antagonism and Kremen may only play a role when cells express a high level of LRP5/6 PMID: 18502762
  7. This study provides the first genetic evidence for a functional interaction of Kremen proteins with Dkk1 as negative regulators of Wnt/beta-catenin signaling. PMID: 18505822

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
In the adult, widely expressed with high levels in heart, lung, kidney, skeletal muscle and testis.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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