ksr-1 Antibody

Code CSB-PA176923XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans ksr-1 Polyclonal antibody
Uniprot No.
Target Names
ksr-1
Alternative Names
ksr-1 antibody; F13B9.5Kinase suppressor of Ras A antibody; EC 2.7.11.1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans ksr-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Serine/threonine-protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. Involved in sex myoblast migration. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Functions redundantly with ksr-2 in the Ras-mediated regulation of larval survival, the development of excretory canal and in mpk-1 phosphorylation in somatic cells. In addition, involved in determining vulval precursor cell fate during vulval induction independently of its kinase activity. Plays a role in egg-laying.
Gene References into Functions
  1. KSR-1 modulates locomotion downstream of, or in parallel to, the Gq-Rho pathway. PMID: 29615470
Protein Families
Protein kinase superfamily, TKL Ser/Thr protein kinase family
Database Links

KEGG: cel:CELE_F13B9.5

STRING: 6239.F13B9.5.2

UniGene: Cel.11005

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