L Antibody

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Code	CSB-PA313164ZA01ZAB
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Target Background

Product Details

Full Product Name

Rabbit anti-Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) L Polyclonal antibody

Uniprot No.

Q05318

Target Names

Alternative Names

LRNA-directed RNA polymerase L antibody; Protein L antibody; Large structural protein antibody; Replicase antibody; Transcriptase) [Includes: RNA-directed RNA polymerase antibody; EC 2.7.7.48); mRNA antibody; guanine-N(7)-)-methyltransferase antibody; EC 2.1.1.56); GDP polyribonucleotidyltransferase antibody; EC 2.7.7.88); Cap-specific mRNA antibody; nucleoside-2'-O-)-methyltransferase 2 antibody; EC 2.1.1.296)] antibody

Raised in

Rabbit

Species Reactivity

Zaire ebolavirus

Immunogen

Recombinant Zaire ebolavirus L protein

Immunogen Species

Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

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Target Background

Function

RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.; RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.

Gene References into Functions

Authors found that the phosphodiester bridge-cleaving and recombination activities of TOP1 are required for the polymerase activity of Ebola virus L protein. PMID: 23658456
A core binding domain spanning amino acids 280-370 of L was sufficient to mediate weak interaction with VP35, while the entire N-terminus up to amino acid 380 was required for strong VP35-L binding. PMID: 23582637

Subcellular Location

Virion. Host cytoplasm.

Database Links

KEGG: vg:911824

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L Antibody

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