lag-2 Antibody

Code CSB-PA338185XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans lag-2 Polyclonal antibody
Uniprot No.
Target Names
lag-2
Alternative Names
lag-2 antibody; let-461 antibody; Y73C8B.4 antibody; Protein lag-2 antibody; Lethal protein 461 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans lag-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Probable ligand for lin-12/Notch and glp-1/Notch receptors and involved in the mediation of Notch signaling. Involved in the lin-12/Notch pathway signaling of cell fate in vulval precursor cells (VPCs) and in the postembryonic mesodermal lineage (M lineage), acting redundantly with dsl-1 and apx-1. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. Required for oocyte growth control, acting redundantly with apx-1, perhaps signaling via the glp-1/Notch pathway. Involved in maintaining the developmentally arrested larval state known as dauer, probably signaling in the glp-1/Notch pathway. Required for normal sleep bout quantity and arousal thresholds during the transition from the last larval stage to adulthood in well-fed animals.
Gene References into Functions
  1. lag-2 promoter contains an element, VPCrep, which mediates repression in all VPCs when the inductive signal is absent, and another promoter element, VPCact, which is required for activation when repression is relieved by the inductive signal. PMID: 21596897
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed in the gonad distal tip cell (DTC) of hermaphrodites.
Database Links

KEGG: cel:CELE_Y73C8B.4

STRING: 6239.Y73C8B.4

UniGene: Cel.1552

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