Lam Antibody

Code CSB-PA362551XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Lam Polyclonal antibody
Uniprot No.
Target Names
Lam
Alternative Names
Lam antibody; CG6944 antibody; Lamin Dm0 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Lam protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane. In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle.
Gene References into Functions
  1. findings reveal coordination of AGO2 and LaminB function to dictate genome architecture and thereby regulate gene expression PMID: 29529026
  2. The loss of lamin-B leads to systemic inflammation and aging. PMID: 25875575
  3. nuclear Wash interacts with B-type Lamin (Lamin Dm0), and, like Lamin, Wash associates with constitutive heterochromatin PMID: 25754639
  4. of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C PMID: 22393432
  5. Rab5 associated in vivo with nuclear Lamin and mushroom body defect (Mud), the Drosophila counterpart of nuclear mitotic apparatus protein (NuMA). PMID: 21987826
  6. Kugelkern and lamin Dm0 affect nuclear shape without requiring filament formation or the presence of a classical nuclear lamina. PMID: 20685963
  7. Lamin mutation is associated with neuromuscular defects and premature aging. PMID: 17565385
  8. analysis of Drosophila and human A-type lamins PMID: 19855837
  9. prometaphase spindle can be made robust to natural fluctuations in motor ratios by a disassembling lamin-B envelope. PMID: 20065089
  10. Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. PMID: 15996653
  11. Molecular interactions with lamin Dm0 may link JIL-1 kinase to nuclear morphology and integrity of nurse cells during oogenesis. PMID: 16254246
  12. The lamin Dm0 allele Ari3 acts as an enhancer of position effect variegation of the wm4 allele in Drosophila. PMID: 16897461
  13. Both lamin Dm0 and C. elegans Ce-lamin bind directly to histone H2A in vitro and this binding requires the nuclear localization signal PMID: 17148572
  14. Induced expression of the farnesylated lamina proteins Lamin B and Kugelkern cause aberrant nuclear shapes and reduce the lifespan of adult flies. PMID: 18494863
  15. developmental disorders caused by lesions in the B-type lamins and interacting proteins PMID: 19218438

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Subcellular Location
Nucleus. Nucleus inner membrane. Nucleus envelope. Nucleus lamina. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm.
Protein Families
Intermediate filament family
Tissue Specificity
Constitutively expressed in all tissues (at protein level). Expressed in spermatocytes (at protein level).
Database Links

KEGG: dme:Dmel_CG6944

STRING: 7227.FBpp0078733

UniGene: Dm.312

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