Lam Antibody

Datasheet

Code	CSB-PA362551XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Lam Polyclonal antibody

Uniprot No.

P08928

Target Names

Lam

Alternative Names

Lam antibody; CG6944 antibody; Lamin Dm0 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Lam protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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■ Customer Reviews

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Target Background

Function

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane. In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle.

Gene References into Functions

findings reveal coordination of AGO2 and LaminB function to dictate genome architecture and thereby regulate gene expression PMID: 29529026
The loss of lamin-B leads to systemic inflammation and aging. PMID: 25875575
nuclear Wash interacts with B-type Lamin (Lamin Dm0), and, like Lamin, Wash associates with constitutive heterochromatin PMID: 25754639
of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C PMID: 22393432
Rab5 associated in vivo with nuclear Lamin and mushroom body defect (Mud), the Drosophila counterpart of nuclear mitotic apparatus protein (NuMA). PMID: 21987826
Kugelkern and lamin Dm0 affect nuclear shape without requiring filament formation or the presence of a classical nuclear lamina. PMID: 20685963
Lamin mutation is associated with neuromuscular defects and premature aging. PMID: 17565385
analysis of Drosophila and human A-type lamins PMID: 19855837
prometaphase spindle can be made robust to natural fluctuations in motor ratios by a disassembling lamin-B envelope. PMID: 20065089
Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. PMID: 15996653
Molecular interactions with lamin Dm0 may link JIL-1 kinase to nuclear morphology and integrity of nurse cells during oogenesis. PMID: 16254246
The lamin Dm0 allele Ari3 acts as an enhancer of position effect variegation of the wm4 allele in Drosophila. PMID: 16897461
Both lamin Dm0 and C. elegans Ce-lamin bind directly to histone H2A in vitro and this binding requires the nuclear localization signal PMID: 17148572
Induced expression of the farnesylated lamina proteins Lamin B and Kugelkern cause aberrant nuclear shapes and reduce the lifespan of adult flies. PMID: 18494863
developmental disorders caused by lesions in the B-type lamins and interacting proteins PMID: 19218438

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Subcellular Location

Nucleus. Nucleus inner membrane. Nucleus envelope. Nucleus lamina. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm.

Protein Families

Intermediate filament family

Tissue Specificity

Constitutively expressed in all tissues (at protein level). Expressed in spermatocytes (at protein level).

Database Links

KEGG: dme:Dmel_CG6944

STRING: 7227.FBpp0078733

UniGene: Dm.312

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Lam Antibody

Product Details

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Target Background