LanA Antibody

Code CSB-PA309530XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) LanA Polyclonal antibody
Uniprot No.
Target Names
LanA
Alternative Names
LanA antibody; lamA antibody; CG10236Laminin subunit alpha antibody; Laminin A chain antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) LanA protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Activates presynaptic signaling involving integrin alpha-PS3/beta-nu and Fak to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with integrin alpha-PS3/beta-nu, glutamate receptor-modulated NMJ growth.
Gene References into Functions
  1. data indicate that synaptic activities down-regulate levels of the retrograde signal LanA to promote neuromuscular junction growth PMID: 23054837
  2. results suggest an evolutionarily conserved role of a member of the laminin gene family in contributing to variation in weight and body composition PMID: 18694491
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane. Cell junction, synapse. Cell projection, axon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Major component of basement membranes. At neuromucular junctions, localizes in synaptic clefts of peri-active zones and in subsynaptic reticula.
Tissue Specificity
Newly formed mesoderm and later prominently expressed in hemocytes, which also synthesize collagen IV. Expressed in muscles.
Database Links

KEGG: dme:Dmel_CG10236

STRING: 7227.FBpp0076722

UniGene: Dm.865

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