Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) LamC Polyclonal antibody

Uniprot No.

Q03427

Target Names

LamC

Alternative Names

LamC antibody; CG10119Lamin-C antibody; pG-IF antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) LamC protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. In spermatocytes, regulates cytokinesis during meiosis.

Gene References into Functions

Lamin C, the sole A-type lamin in Drosophila, contributes to the process of thorax closure in pupa. PMID: 29559239
Human progeroid syndrome-modeled LamC mutations induced premature aging in adult flight muscles, including decreased levels of specific mitochondrial protein transcripts (RNA) and progressive mitochondrial degradation. They also induced the accelerated appearance of other phenotypes associated with aging. PMID: 27451905
The critical function of A-type lamin C proteins in Drosophila musculature is to maintain proper function and morphology of tendon cells. PMID: 22982669
Study finds that C-terminal fragments of DFz2 accumulate in nuclear foci in association with large RNA granules localizing to the space between the inner PMID: 22579286
Drosophila lamC has a tissue-specific role during development and is required for chromatin organization. PMID: 20505245
larval muscle-specific expression of a truncated form of Lamin C lacking the N-terminal head (Lamin C DeltaN) caused muscle defects and semi-lethality, with adult 'escapers' possessing malformed legs. PMID: 20702563
Data provide the first detailed genetic analysis of the LamC gene and support using Drosophila as a model to study the role of lamins in disease. PMID: 15965247

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Subcellular Location

Nucleus. Nucleus lamina.

Protein Families

Intermediate filament family

Tissue Specificity

First detected from late stage 12 in the oenocytes, abdominal segments, hindgut and posterior spiracles, with expression increasing in stage 13 (at protein level). In stage 14, also becomes detectable in the foregut (at protein level). Stage 15 shows expr

Database Links

KEGG: dme:Dmel_CG10119

STRING: 7227.FBpp0305369

UniGene: Dm.2782

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LamC Antibody

Product Details

Customer Reviews and Q&A

Target Background