Lar Antibody

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Code	CSB-PA322301XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Lar Polyclonal antibody

Uniprot No.

P16621

Target Names

Lar

Alternative Names

Lar antibody; CG10443 antibody; Tyrosine-protein phosphatase Lar antibody; EC 3.1.3.48 antibody; Protein-tyrosine-phosphate phosphohydrolase antibody; dLAR antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Lar protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). It controls motor axon guidance. In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl. Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function.

Gene References into Functions

The authors found that the depth of the final layer of stable photoreceptor axon termination relied primarily on the cumulative amount of LAR and Ptp69D cytoplasmic activity, while specific features of their ectodomains contribute to the choice between two synaptic layers, M3 and M6, in the medulla. PMID: 29116043
Fat2/Lar signaling mediates short-range communication between neighboring cells instead of transmitting long-range information across a tissue. PMID: 28292425
The results of this study suggested that loss of Lar alters sLNv axonal targeting in the dorsal protocerebrum during embryonic or early larval development, thereby impairing PDF signaling, synchronization of the circadian network, and rhythmic activity. PMID: 27030770
the Lar receptor tyrosine phosphatase appears to polarize and retain GSCs through maintenance of localized E-cadherin-based adherens junctions PMID: 22378638
the crystal structures of the first and second immunoglobulin-like domains of the Drosophila type IIa receptor Dlar and its mouse homolog LAR were reported. PMID: 21402080
Drosophila caskin (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically with the leukocyte common antigen-related PMID: 21430143
Receptor phosphatase Dlar regulates the formation and maintenance of presynaptic proteins. PMID: 11931739
Functions of the ectodomain and cytoplasmic protein-tyrosine-phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo were studied. PMID: 12972609
Results suggest that Liprin-alpha does not simply act by regulating receptor tyrosine phosphatase LAR localization but also has LAR-independent functions PMID: 16864797
During development of the larval mushroom body, Lar is expressed within an expanded core region including somewhat older axons. Lar is necessary for the axonal branching decisions that create the lobes. PMID: 18356078
LAR function in R7 is independent of its phosphatase activity, but requires structural features that allow dimerization and may promote the assembly of downstream effectors. PMID: 19889974

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Protein-tyrosine phosphatase family, Receptor class 2A subfamily

Tissue Specificity

Selectively expressed in a subset of axons and pioneer neurons in the embryo.

Database Links

KEGG: dme:Dmel_CG10443

STRING: 7227.FBpp0303681

UniGene: Dm.24416

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Lar Antibody

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