let-418 Antibody

Code CSB-PA188393XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans let-418 Polyclonal antibody
Uniprot No.
Target Names
let-418
Alternative Names
let-418 antibody; evl-11 antibody; F26F12.7 antibody; Protein let-418 antibody; Lethal protein 418 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans let-418 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide genes in response to fungal infection.
Gene References into Functions
  1. These suppressors might represent direct competitors of LET-418 complexes for chromatin regulation of crucial genes involved in the transition to postembryonic development PMID: 28007841
  2. LET-418/Mi2 could be part of a system that drives development and reproduction with concomitant life-reducing effects later in life. PMID: 23815345
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in embryos and larva.
Database Links

KEGG: cel:CELE_F26F12.7

STRING: 6239.F26F12.7

UniGene: Cel.16862

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