let-653 Antibody

Code CSB-PA583540XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans let-653 Polyclonal antibody
Uniprot No.
Target Names
let-653
Alternative Names
let-653 antibody; C29E6.1 antibody; Protein let-653 antibody; Lethal protein 653 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans let-653 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for epithelial tube development and shaping. Involved in the morphogenesis and function of the three unicellular tubes of the excretory system, the canal cell, the duct cell and the pore cell. Also plays a role in cuticle development, alae formation and shaping of the vulval lumen. Required for larval development.
Gene References into Functions
  1. hese data support a model in which the PAN domains regulate the ability of the LET-653 ZP domain to interact with other factors at the apical membrane, and this ZP domain interaction promotes expansion and maintenance of lumen diameter. PMID: 27482894
Subcellular Location
[Isoform b]: Apical cell membrane; Peripheral membrane protein; Lumenal side. Secreted, extracellular space. Secreted.
Tissue Specificity
[Isoform b]: Expressed in external cuticle-producing epithelial cells including the epidermis, vulva, rectum, excretory duct and excretory pore.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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