let-756 Antibody

Code CSB-PA612114XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans let-756 Polyclonal antibody
Uniprot No.
Target Names
let-756
Alternative Names
let-756 antibody; C05D11.4Protein let-756 antibody; Lethal protein 756 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans let-756 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for larval development. Probably by binding receptor egl-15, regulates negatively membrane protrusion from body wall muscles during larval development.
Gene References into Functions
  1. the EFISIA motif in the core of LET-756 is essential for its biological activity PMID: 15199049
  2. LET-756, like vertebrate FGF9, -16, and -20, belongs to the FGF9 family, whereas EGL-17, like vertebrate FGF8, -17, and -18, could be included in the FGF8 family [review] PMID: 15614779
  3. LET-756 exerts its functions through a balance between a synergy of several nuclear localization signals and attenuated secretion signal. PMID: 16487967
Subcellular Location
Nucleus. Membrane; Peripheral membrane protein.
Protein Families
Heparin-binding growth factors family
Tissue Specificity
Expressed in pharynx, CAN neuron and body wall muscles.
Database Links

KEGG: cel:CELE_C05D11.4

STRING: 6239.C05D11.4

UniGene: Cel.19648

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