lin-28 Antibody

1. show that CED-3 caspase and the E3 ubiquitin ligase UBR-1 form a complex that couples their in vivo activities, allowing for recognition and rapid degradation of LIN-28 and thus facilitating a switch in developmental programs PMID: 28602583
2. LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans PMID: 26811380
3. LIN-28 regulates the expression of the let-7 microRNA by binding its primary transcript in a previously unknown region, revealing a novel regulatory mechanism. PMID: 25805859
4. lin-28's two-step mechanism may be an essential feature of its evolutionarily conserved role in cell fate succession PMID: 22457637
5. LIN28 can directly inhibit let-7g biogenesis at the Dicer processing step PMID: 21815640
6. Lin-28 binds endogenous primary let-7 microRNA transcripts co-transcriptionally. PMID: 21297634
7. lin-28, the RNA binding protein, is required for the correct timing of let-7 RNA and let-7:gfp expression. PMID: 12871707
8. These results suggest that lin-28 expression is regulated by multiple independent mechanisms. PMID: 17139256
9. LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans PMID: 19713957

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KEGG: cel:CELE_F02E9.2

STRING: 6239.F02E9.2a

UniGene: Cel.22515