lin-3 Antibody

1. Even a short 58 bp cis-regulatory fragment from C. angaria with this single E-box is able to replace the three transcription factor binding sites at the endogenous C. elegans lin-3 locus, resulting in the wild-type expression level. Thus, regulatory evolution occurring in cis within a 58 bp lin-3 fragment, results in a strict requirement for the NHR binding site and a second E-box in C. elegans PMID: 27588814
2. LIN-1 binds to, and activates transcription of, the key pro-apoptotic gene egl-1 Our results provide the first evidence that EGF induces PCD at the whole organism level and reveal the molecular basis for the death-promoting function of LIN-3/EGF PMID: 25144461
3. widespread ectopic expression of a lin-3 growth factor mRNA at concentrations much lower than that in the normal domain of expression can abnormally activate the Ras pathway and alter cell fates PMID: 22242000
4. Study demonstrated that let-765 positively regulates the RAS pathway and antagonizes synMuv activity at the level of lin-3/EGF PMID: 20230814
5. Nuclear hormone receptor(s), are necessary for lin-3 transcription in anchor cells and thus are involved in vulval development. PMID: 14660442
6. The SynMuv A and SynMuv B gene classes are functionally redundant for transcriptional repression of the key target gene, lin-3/EGF, in the hypodermis. PMID: 16678779

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KEGG: cel:CELE_F36H1.4

UniGene: Cel.18204