lin-41 Antibody

1. LIN-41 represses translation of spn-4 and meg-1during oocyte meiotic maturation and the oocyte-to-embryo transition. PMID: 28576864
2. Study reports that the stem cell fate regulator LIN41 silences mRNAs through two distinct and separable mechanisms: translational repression or degradation. Choice of mechanism is specified by the location of the LIN41- binding site on the target mRNA. PMID: 28111013
3. Lin-41 regulates the gene expression required for timely centrosome elimination around the diplotene stage in female germ cells. PMID: 26764090
4. regulation of LIN-41 alone is necessary and sufficient to prevent vulval rupturing. Hence, let-7 does not function to reduce gene expression noise broadly, but to direct vulval development through extensive regulation of a single, defined target PMID: 25669883
5. LIN-41 appears to function in the germline and the soma via different molecular mechanisms PMID: 25167051
6. In older anterior ventral microtubule axons, let-7inhibits regeneration by down-regulating LIN-41, an important AVM axon regeneration-promotingfactor. PMID: 23599497
7. NMR structure reveals details of the binding of let-7 miRNA to lin-41 mRNA which involves formation of a complex with non-canonical structural elements within the seed region. PMID: 20660479
8. lin-41, a homologue of the vertebtate lin-41, functions as a heterochronic gene. PMID: 16477647
9. two novel, gain-of-function alleles of lin-41. Small changes affecting LIN-41 could have been significant for male tail evolution.lin-41 governs the timing and extent of male tail tip morphogenesis in a dose-dependent manner. PMID: 16806150
10. NMR solution structure of a model mimicking the interaction of let-7 miRNA with its complementary site in the 3' untranslated region of the lin-41 mRNA. PMID: 18296482

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KEGG: cel:CELE_C12C8.3

STRING: 6239.C12C8.3a.1

UniGene: Cel.5222