lin Antibody

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Code	CSB-PA893232XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) lin Polyclonal antibody

Uniprot No.

Q9V4Z9

Target Names

lin

Alternative Names

lin antibody; CG11770Protein lines antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) lin protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Has a dual role as a segment polarity protein and as a modulator of the Abd-B protein. Required for Abd-B to activate the transcription of genes (including ems, cut and sal) that are involved in posterior spiracle morphogenesis. Also required for Abd-B to form an eighth abdominal denticle belt. Acts in a hierarchy downstream of drm and upstream of bowl during foregut and hindgut patterning and morphogenesis. Involved in cell rearrangement during elongation of the embryonic hindgut. Required to regulate expression of embryonic hindgut patterning genes in order to establish the large intestine and at least some rectum, and to repress small intestine fate. Required for late wingless (wg)-dependent cell fate specification in the dorsal embryonic epidermis. Acts in concert with wg to regulate expression of wg itself and also to regulate wg-target genes. May have a role in ventral epidermal patterning, independent of wg signaling.

Gene References into Functions

data show that drm encodes a zinc finger protein that is a member of the Odd-skipped family. drm expression is localized to the developing midgut-hindgut junction, while lines is broadly expressed throughout the gut primordium PMID: 12117814
Drm and Lines regulate Bowl protein accumulation and consequent patterning in the epithelia of the foregut, hindgut, and imaginal discs. PMID: 15769943
Reciprocal roles are reported for bowl and lin in specifying the peripodial epithelum and the disc proper of the wing. PMID: 18701548
Here we show that Lines accumulates in nuclei in the presumptive tarsus and the inter-joints of proximal leg segments and governs the formation of these structures by destabilizing the nuclear protein Bowl PMID: 19324031

Subcellular Location

Cytoplasm. Nucleus. Note=Cytoplasmic in the half of the parasegment, posterior to the engrailed (en) domain, and nuclear in the half of the parasegment anterior to the en domain.

Protein Families

Protein lines family

Tissue Specificity

Expressed throughout the embryo, including the hindgut, posterior midgut and embryonic epidermis.

Database Links

KEGG: dme:Dmel_CG11770

STRING: 7227.FBpp0087732

UniGene: Dm.1802

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lin Antibody

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