lok Antibody

1. this study demonstrates, that Lok kinase activation is required for the DNA damage-mediated disruption of adult stem cell self-renewal and lineage differentiation, and might also offer novel insight into how DNA damage causes tissue aging and cancer formation. PMID: 27729408
2. FHA domain in Mnk plays dual functions in mediating embryonic DNA damage responses by means of its phosphopeptide-binding ability: activating Mnk in nucleus upon DNA damage &recruiting Mnk to multiple subcellular structures independently of DNA damage PMID: 25808488
3. We conclude that the primary responsibility for maintaining genome integrity in the male germline lies with Chk2, and that P53 is required to reconstitute the germline when cells are eliminated owing to unrepaired DNA damage. PMID: 24586185
4. nuclear retention involves Chk2-mediated inactivation of the Drosophila stem loop binding protein (SLBP), the levels of which are specifically depleted in damaged nuclei following Chk2 phosphorylation, an event that contributes to nuclear fallout. PMID: 24835465
5. while Chk2 functions by activating the p53-dependent apoptotic cascade, Chk2 also functions independently of p53 to limit survival. PMID: 21655087
6. Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. PMID: 20838898
7. The DNA damage-activated kinases Chk1 and Chk2 may be involved in tau phosphorylation and toxicity in the pathogenesis of Alzheimer's disease. PMID: 20159774
8. plays a crucial role in the DNA damage response pathway mediating cell cycle arrest and apoptosis, and the ATM-Chk2 pathway is likely conserved in Drosophila PMID: 11728459
9. regulates irradiation-induced, p53-mediated apoptosis in Drosophila PMID: 12172011
10. in flies, chk2 is involved in monitoring double-strand breaks (DSBs) caused by irradiation during S and G2 phases PMID: 12663536
11. Dmnk plays an important role in a mitotic checkpoint in syncytial embryos. PMID: 12804777
12. Drosophila has Chk2- and p53-independent pathways to activate caspases and induce apoptosis in response to IR. PMID: 16785441
13. The mnk (also known as loki) gene encodes Checkpoint kinase 2 (Chk2), which functions in DNA-damage signal transduction. PMID: 17409117
14. Genetic screening was performed to identify novel components of the Chk2 signaling pathway in Drosophila. PMID: 18612247
15. Data propose that hid expression is activated in a pole cell-specific manner by loki/p53 and dpp/egr during embryogenesis. PMID: 19382940

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KEGG: dme:Dmel_CG10895

STRING: 7227.FBpp0080860

UniGene: Dm.475