lola Antibody

Code CSB-PA803050XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) lola Polyclonal antibody
Uniprot No.
Target Names
lola
Alternative Names
lola antibody; CG12052 antibody; Longitudinals lacking protein antibody; isoforms F/I/K/T antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) lola protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
Gene References into Functions
  1. In developing axons, lola cell trafficking is regulated by cGMP-dependent protein kinase. PMID: 27098704
  2. Loss of Lola Causes Brain Tumors. PMID: 24631403
  3. Different lola isoforms, each having unique C-termini and zinc finger domains, may control different aspects of proliferation and differentiation in the male germline and somatic cyst stem cell lineages. PMID: 23159836
  4. Lola suppresses expression of the actin nucleation factor Spire, and this is crucial for its ability to promote growth of motor axons in vivo. PMID: 22129300
  5. Lola is the examplar of a class of axon guidance molecules that control axon patterning PMID: 11880341
  6. Alternative splicing of the lola gene creates a family of 19 transcription factors and explains how a small genome encodes all the information that is necessary to specify the enormous diversity of axonal trajectories. PMID: 12897787
  7. lola plays a critical role in programmed cell death in the ovary PMID: 17336958
  8. We propose that Lola functions as a general transcription factor that regulates the expression of multiple genes ultimately controlling PN identity and wiring specificity. PMID: 17634136
  9. Lola antagonizes Notch-dependent gene expression and Notch-dependent fate transformation. Expression analysis shows that Lola is constitutively present in all photoreceptors and cone cells PMID: 18053694

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Subcellular Location
Nucleus.
Tissue Specificity
By stage 11, isoform F is expressed throughout the mesoderm whereas isoform T, and at low levels isoform I, is expressed throughout the ectoderm. Isoform K is expressed in both mesoderm and ectoderm. Expression becomes restricted during later stages; star
Database Links

STRING: 7227.FBpp0088384

UniGene: Dm.11710

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