Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans lrk-1 Polyclonal antibody

Uniprot No.

Q9TZM3

Target Names

lrk-1

Alternative Names

lrk-1 antibody; T27C10.6 antibody; Leucine-rich repeat serine/threonine-protein kinase 1 antibody; EC 2.7.11.1 antibody; Leucine-rich repeats antibody; ras-like domain antibody; kinase protein 1 antibody; PARK8-related kinase antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans lrk-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite-specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response.

Gene References into Functions

LRRK2 functions together with a second Parkinson's disease-associated gene, RAB7L1, within an evolutionarily conserved genetic module in diverse cellular contexts. PMID: 27424887
Study investigated the role of UNC-23 and HSP-1 on LRK-1 function in C. elegans; results suggest that the UNC-23-HSP-1 chaperone complex regulates LRK-1 localization to the Golgi apparatus and consequently determines the polarized sorting of synaptic vesicle proteins to the axons. PMID: 26853528
Lack of Grx1 homolog exacerbates LRRK2-mediated dopaminergic neurodegeneration in Caenorhabditis elegans. PMID: 25355420
Findings establish a critical functional link between LRRK2 and ER stress. PMID: 21857923
Study identified a novel protein kinase LRK-1, a C. elegans homolog of the familial Parkinsonism gene PARK8/LRRK2 that is required for polarized localization of synaptic vesicle proteins. PMID: 17346966
LRRK2 can regulate the mitochondrial physiology of Caenorhabditis elegans, possibly via the worm lrk-1 pathway. PMID: 18322385
Due to the similarity of the C. elegans proteins to human LRRK2 and PINK1, we suggest a common role of both factors in cellular functions including stress response and regulation of neurite outgrowth PMID: 19251702

Hide All

Subcellular Location

Golgi apparatus.

Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family, ROCO subfamily

Tissue Specificity

Expressed in cell bodies, but not in dendritic or axonal processes, of adult head neurons. Also present in non-neuronal tissues, such as the body wall musculature and the epithelial cells of the nematode vulva.

Database Links

KEGG: cel:CELE_T27C10.6

STRING: 6239.T27C10.6

UniGene: Cel.20322

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Code	CSB-PA883321XA01CXY
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

lrk-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background