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spr-5 Antibody

Datasheet
Code CSB-PA894087XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans spr-5 Polyclonal antibody
Uniprot No.
Q9XWP6
Target Names
spr-5
Alternative Names
spr-5 antibody; Y40B1B.6Probable lysine-specific histone demethylase 1 antibody; EC 1.-.-.- antibody; P110b homolog antibody; Suppressor of presenilin 5 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans spr-5 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Related Products

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Target Background

Function
Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together with met-2, set-17 and set-26, required for transgenerational fertility.
Gene References into Functions
  1. SPR-5 interacts with FNCM-1. SPR-5 absence suppresses the embryonic lethality and larval arrest observed in fncm-1 mutants. PMID: 29588287
  2. germ cells deficient for spr-5 and let-418 mainly reprogram as neurons, suggesting that neuronal fate might be the first to be derepressed in early embryogenesis. PMID: 24749077
  3. SPR-5 and MET-2 function cooperatively to reestablish an epigenetic ground state during passage through the germ line. PMID: 24979765
  4. Studies indicate that cellular identity in is the sum of interplay between PcG and Trx-G group proteins, as well as histone modifying enzymes MES-4 and SPR-5. PMID: 21538806
  5. Data suggest that SPR-5 may function directly in DSBR. PMID: 21768382

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Subcellular Location
Nucleus.
Protein Families
Flavin monoamine oxidase family
Database Links
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