LSM1 Antibody

1. P-bodies like LSM1 form in response to stress and act as sites of mRNA storage and degradation. Here the authors identify the mRNA targets of P-bodies during DNA replication stress, and show that P-body proteins act to prevent toxic accumulation of these target transcripts. PMID: 28916784
2. The authors identify histone mRNAs as substrates of the Lsm1-7-Pat1 complex in yeast, and show that abnormally high amounts of histones accumulate in lsm1Delta mutant cells. PMID: 21487390
3. Mutations led to impairment of mRNA decay, did not affect the localization of the Lsm1p-7p complex. mRNA 3'-end protection could be indicative of the binding of the Lsm1p-7p complex to the mRNA. PMID: 15716506
4. Lsmlp may confer protection against UV-radiation damage by protecting the 3' ends of mRNAs from exosome-dependent 3' to 5' degradation as part of a novel RAD5-mediated, PCNA-K164 ubiquitylation-independent subpathway of PRR. PMID: 19024647
5. Results describe a range of mutant and hybrid Lsm1 and Lsm8 proteins, shedding light on the relative importance of their various domains in determining their localization and ability to support growth. PMID: 19490016
6. LSM1 over-expression in the yeast Saccharomyces cerevisiae inhibits growth primarily due to U6 snRNA depletion, thereby altering pre-mRNA splicing. PMID: 19596813

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KEGG: sce:YJL124C

STRING: 4932.YJL124C