MEKK1 Antibody

1. Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 activation concomitantly with MEKK1 and MKK2 phosphorylation. PMID: 24801600
2. Ca(2+) signaling occurred upstream of the MEKK1-MKK2 pathway. MEKK1 was phosphorylated by calcium/calmodulin-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1. PMID: 23857079
3. MEKK1 plays a key role in transducing the l-Glu signal that elicits large-scale changes in root architecture, and provide genetic evidence for the existence in plants of an external glutamate (l-Glu) signalling pathway analogous to that found in animals. PMID: 23574009
4. Data suggest that the MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates MEKK2 and activation of MEKK2 triggers SUMM2-mediated immune responses. PMID: 22643122
5. CRLK1 interacts with MEKK1 in vitro and in planta during cold treatment. PMID: 20724845
6. An analysis of the interation of MEKK1 and MEK1 in response to wounding stress in A. thaliana seedlings is presented. PMID: 16211390
7. MEKK1 is essential for activation of MPK4 and negatively regulates temperature-sensitive and tissue-specific cell death and H(2)O(2) accumulation that are dependent on both RAR1 (resistance protein function) and SID2 (isochorismate synthase) PMID: 17023433
8. This study demonstrated that analysis of plants carrying T-DNA knockout alleles indicated that MEKK1 is required for flg22-induced activation of MPK4. PMID: 17142480
9. Treatment with elevated levels of sodium chloride improves the growth of mekk1 transgenic plants;the mekk1;mpk4 double-mutant combination causes seedling lethality. PMID: 17572407
10. MEKK1 is a bifunctional protein: it binds to the promoter of the WRKY53 gene regulating the switch from a leaf age dependent to a plant age dependent expression PMID: 17587183
11. Activation of MPK4 by flg22 is impaired in the mkk1 mkk2 double mutants, suggesting that MKK1 and MKK2 function together with MPK4 and MEKK1 in a MAP kinase cascade to negatively regulate innate immune responses in plants. PMID: 18982020

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KEGG: ath:AT4G08500

STRING: 3702.AT4G08500.1

UniGene: At.21066