Tak1 Antibody

1. Imd is rapidly Lys-63-polyubiquitinated at lysine residues 137 and 153 by the sequential action of two E2 enzymes, Ubc5 and Ubc13-Uev1a, in conjunction with the E3 ligase Diap2. Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin. PMID: 28377500
2. Tak1 is dispensable in the Slpr-dependent process of dorsal closure; it does not induce or inhibit morphogenetic JNK signaling. PMID: 24429281
3. The TAK1-associated Binding Protein 2 (TAB2) was linked with the TAK1-Trabid interaction through its Zinc finger domain that pacified the TAK1 signal PMID: 24586180
4. When treated with autophagy inhibitors, the level of TAK1-induced cytotoxicity or cell death was significantly attenuated, indicating that TAK1 induces cytotoxic autophagic cell death. PMID: 23532117
5. evidence that TAK1 is a target for YopJ-mediated inhibition. PMID: 22802624
6. that dpp induced non-autonomous apoptosis through TGFbeta activated kinase 1 (TAK1) PMID: 22114909
7. specific stimuli use different mechanisms to recruit distinct MAP3Ks to regulate the JNK pathway PMID: 12351623
8. TAK1 functions as both the Drosophila IkappaB kinase-activating kinase and the JNK kinase-activating kinase PMID: 14519762
9. Relish limits the duration of JNK activation in response to Gram-negative infections by degradation of TAK1, leading to rapid termination of JNK signaling, resulting in a transient JNK-dependent response that precedes sustained induction of immune loci. PMID: 15037551
10. dTAK1 is not required for Relish activation, but instead is required in JNK signaling for antimicrobial peptide gene expression. PMID: 16763552

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KEGG: dme:Dmel_CG18492

STRING: 7227.FBpp0077011

UniGene: Dm.6425