mal3 Antibody

1. Microtubule-bound microtubule-associated proteins Mal3 (Mal3) shows that Mal3 makes a distinctive footprint on the microtubule lattice. PMID: 29235477
2. we show that Mal3, the fission yeast member of the EB1 family of conserved microtubule plus-end tracking proteins, is required for karyogamy, oscillatory nuclear movement, and proper segregation of chromosomes during meiosis PMID: 24196444
3. Mal3 deletion mutant cells have a disordered cytoplasmic microtubule structure during karyogamy and initiate meiosis before completion of karyogamy. PMID: 23755176
4. Using cryo-electron microscopy, subnanometer single-particle reconstruction, and fluorescence imaging, study presents a pseudoatomic model of how the calponin homology (CH) domain of the fission yeast EB Mal3 binds to the end regions of growing microtubules. PMID: 22500803
5. A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules. PMID: 22134091
6. mal3 mutant phenotype can be suppressed by the presence of extra Spc7 PMID: 15371542
7. These results show that microtubule dynamics is important for coordinated execution of mitotic events, in which Mal3 plays a vital role. PMID: 16394105
8. Using electron microscopy (EM) and high-resolution surface shadowing we have studied the microtubule-binding properties of the fission yeast EB1 homolog Mal3p. PMID: 17190604
9. Mal3 promotes assembly by binding to freshly formed tubulin polymer and particularly favors any with A-lattice arrangement PMID: 18794845
10. Mal3 stabilizes microtubules not by preventing catastrophe at the microtubule tip but by inhibiting lattice depolymerization and enhancing rescue. PMID: 19740752

Show More

Hide All

KEGG: spo:SPAC18G6.15

STRING: 4896.SPAC18G6.15.1