MAN1 Antibody

Datasheet

Code	CSB-PA923602XA01DLU
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) MAN1 Polyclonal antibody

Uniprot No.

Q7JRE4

Target Names

MAN1

Alternative Names

MAN1 antibody; CG3167Inner nuclear membrane protein Man1 antibody; LEM domain-containing protein Man1 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) MAN1 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Inner nuclear membrane protein. Acts as a negative regulator of the BMP (Dpp) signaling cascade during crossvein development in pupal wings and possibly during synaptic transmission at the neuromuscular junction (NMJ). Appears to be required for pupal development and consequently transition to the adult stage. During pupal development, plays essential and redundant functions with the other LEM domain proteins; bocks and Ote.

Gene References into Functions

MAN1 negatively regulates accumulation and distribution of bone morphogenetic protein signaling. PMID: 27848060
neither Bocks nor Ote rescued dMAN1-/- mutant phenotypes, implying that dMAN1 makes unique contributions to wing development PMID: 24700158
Genetic interaction experiments suggest that MAN1 is a BMP signaling antagonist both at the neuromuscular junction and during crossvein formation PMID: 20036230
description of the Drosophila melanogaster LEM-domain protein encoded by the gene CG3167 which is the putative ortholog to vertebrate MAN1; concluded that MAN1 protein is not a limiting component of the nuclear architecture in Drosophila cultured cells PMID: 16439308
Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein PMID: 18723885

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Subcellular Location

Nucleus inner membrane; Multi-pass membrane protein. Cytoplasm. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle pole.

Database Links

KEGG: dme:Dmel_CG3167

STRING: 7227.FBpp0072075

UniGene: Dm.7321

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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