mars Antibody

Code CSB-PA765960XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) mars Polyclonal antibody
Uniprot No.
Target Names
mars
Alternative Names
mars antibody; gkap antibody; CG17064Guanylate kinase-associated protein mars antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) mars protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Cell cycle regulator.
Gene References into Functions
  1. The Drosophila eye was used as a model system to characterize the function of the mars gene in cell-cycle regulation. PMID: 15922738
  2. Mars mediates spatially controlled dephosphorylation of dTACC, which is critical for spindle stabilization. PMID: 18625841
  3. results show that Mars is mainly localized on the kinetochore microtubules during mitosis; study provided further evidence showing that Mars is required for the assembly of kinetochore microtubules PMID: 18761010
  4. Mars is an important linker between the spindle and the centrosomes that is required for proper spindle organization during the rapid mitotic cycles in early embryogenesis. PMID: 19174464
  5. mars and tlk function in parallel and a balance between mars activity and tlk activity is required for cells to progress through mitosis correctly, thus ensuring chromosome fidelity PMID: 19486529

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Subcellular Location
Cell membrane; Peripheral membrane protein. Nucleus, nucleoplasm. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell membrane of epithelial cells. Its subcellular localization dynamically changes during cell-cycle progression. At the prophase, it concentrates at the nucleoplasm. In the metaphase cells, it becomes diffusive in the cytoplasm and some is concentrated at the mitotic spindles and spindle poles.
Protein Families
SAPAP family
Tissue Specificity
Expressed in the central nervous system and at different stages of gametogenesis. In embryos, it is expressed in central nervous system and brain. In testis, it is strongly expressed in pre-meiotic germ cells, but is not found in somatic or post-meiotic c
Database Links

KEGG: dme:Dmel_CG17064

STRING: 7227.FBpp0290601

UniGene: Dm.602

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