YDJ1 Antibody

1. The authors provide genetic, biochemical, and biophysical evidence that the Ydj1p CaaX motif is isoprenylated but not cleaved and carboxylmethylated. PMID: 27525482
2. Ydj1 is required for the formation of Dhh1 complexes. PMID: 26392412
3. Ydj1 directs disaggregation activity of the Hsp100-based machinery to provide stress protection. PMID: 25329162
4. The chaperone Ydj1 interacts specifically with mutant septins during septin quality control. PMID: 25673805
5. Results show that Hsp70 and the Ydj1 and Sis1 Hsp40 proteins accumulated in stress granules and defects in these proteins led to decreases in the disassembly and/or clearance of stress granules. PMID: 26199455
6. Ydj1 is a yeast Type I Hsp40 in a highly conserved alpha-helical N-terminal J-domain, a disordered middle region (a glycine/phenylalanine (G/F)), a Zinc finger domain (ZFLR or Cys-rich domain) and a two C-terminal sub-domains. PMID: 22011374
7. Ydj1p/Hlj1p catalyzes CFTR degradation PMID: 15342786
8. the hydrophobic pocket located on Ydj1 plays a critical role in its molecular chaperone activity by mediating interactions with the non-native polypeptides PMID: 15500443
9. crystal structure of the C-terminal fragment of yeast Hsp40 Ydj1 that is responsible for Ydj1 dimerization PMID: 15701512
10. The introduction of YDJ1p improves secretory proteins in Pichia pastoris secretion 4-7 times. PMID: 16889384
11. ydj1delta yeast exhibit phenotypes consistent with cell-wall defects, and these phenotypes were improved by Mid2p or Pkc1p overexpression PMID: 17237519
12. Genetic experiments showed that Ydj1 is not essential for viability; however, Stability experiments revealed that only Ydj1-protected Hsp70 proteins can hydrolyze ATP under prolonged stress. PMID: 17985367
13. Ydj1 is identified as being important for maintaining steady-state levels of protein kinases after screening several chaperones and cochaperones in gene deletion mutant strains. PMID: 18443039
14. Results indicate that farnesylation is a major factor contributing to the specific requirement for Ydj1 in promoting proper regulation and activation of diverse Hsp90 clients. PMID: 18829866
15. The combined action of a farnesyl moiety and zinc finger-like region enable Type I Hsp40s to recognize amyloid-like substrates and prevent formation of cytotoxic protein species. PMID: 19056735
16. A unique motif that is selectively recognized by Ydj1p, was computationally identified. PMID: 19549854

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KEGG: sce:YNL064C

STRING: 4932.YNL064C