MCA1 Antibody

1. The polyunsaturated fatty acid-producing strain also showed great increase in metacaspase Yca1p activity, suggesting cells could die by caspase-mediated cell death. PMID: 26833421
2. The yeast metacaspase regulates both proteolytic activities through the ubiquitin-proteasome system and ceramide metabolism as revealed by proteome and metabolome profiling of YCA1-knock-out cells during acetic-acid induced programmed cell death. PMID: 26269384
3. Using a combination of proteomics and , it was shown that YCA1 deletion down-regulated glycolysis, the TCA cycle and alcoholic fermentation compared with WT cells. PMID: 25697364
4. Life-span extension and aggregate management by Mca1 was only partly dependent on its conserved catalytic cysteine, which suggests that Mca1 harbors both caspase-dependent and independent functions related to life-span control. PMID: 24855027
5. protein degradation factors such as Cdc48 co-localize with Yca1 to the insoluble fraction, supporting the hypothesis that Yca1 may act primarily to dissolve or reduce accumulated aggregates. PMID: 23376483
6. structural and biochemical characterization identifies Yca1 as a Ca(2+)-activated cysteine protease that may cleave specific substrates during stress response in yeast. PMID: 22761449
7. the aggregation propensity of the potential yeast prion protein Mca1 in vivo is strongly accelerated by a short peptide segment preceding its Q/N-rich region PMID: 20360952
8. Data show that Yca1 protein complexes are enriched for aggregate-remodeling chaperones that colocalize with Yca1-GFP fusions. PMID: 20624963
9. alternative death pathways can be activated in yeast acetic acid-induced programmed cell death, one dependent on cyt c release, which requires YCA1, and the other(s) independent on it. PMID: 19941863
10. YCA1 overexpression, without any external stimulus, had a detrimental effect on growth and viability of ubp10 cells accompanied by an increase of apoptotic cells. PMID: 15489197
11. Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae. PMID: 16301538
12. programmed cell death in wild-type cells occurs via a Yca1p caspase and a non-caspase route with similar characteristics PMID: 17156780
13. Yca1p participates in the G2/M mitotic checkpoint in the yeast cell cycle. PMID: 18698411

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KEGG: sce:YOR197W

STRING: 4932.YOR197W