cel-1 Antibody

Code CSB-PA615037XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans cel-1 Polyclonal antibody
Uniprot No.
Target Names
cel-1
Alternative Names
cel-1 antibody; C03D6.3mRNA-capping enzyme [Includes: Polynucleotide 5'-triphosphatase antibody; EC 3.1.3.33 antibody; mRNA 5'-triphosphatase antibody; TPase); mRNA guanylyltransferase antibody; EC 2.7.7.50 antibody; GTP--RNA guanylyltransferase antibody; GTase)] antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans cel-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus via a covalent enzyme-GMP reaction intermediate.
Gene References into Functions
  1. mRNA capping enzyme is required for Caenorhabditis elegans viability PMID: 12576475
  2. CEL-1 and capping are essential for gene expression in metazoans PMID: 12576476
Subcellular Location
Nucleus.
Protein Families
Non-receptor class of the protein-tyrosine phosphatase family; Eukaryotic GTase family
Database Links

KEGG: cel:CELE_C03D6.3

STRING: 6239.C03D6.3a

UniGene: Cel.8014

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