Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) HSP70-1 Polyclonal antibody

Uniprot No.

P22953

Target Names

HSP70-1

Alternative Names

HSP70-1 antibody; ERD2 antibody; HSC70-1 antibody; MED37_4 antibody; MED37E antibody; At5g02500 antibody; T22P11.90Heat shock 70 kDa protein 1 antibody; Heat shock cognate 70 kDa protein 1 antibody; Heat shock cognate protein 70-1 antibody; AtHsc70-1 antibody; Heat shock protein 70-1 antibody; AtHsp70-1 antibody; Protein EARLY-RESPONSIVE TO DEHYDRATION 2 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana HSP70-1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). Probably involved in defense response. Chaperone involved in protein targeting to chloroplasts. May cooperate with SGT1 and HSP90 in R gene-mediated resistance towards the oomycete Hyaloperonospora parasitica (downy mildew). Plays a role with WPP-domain proteins in facilitating WIT1 nuclear envelope targeting. Modulates stomatal aperture in response to various environmental conditions and physiological responses to the hormone abscisic acid (ABA).

Gene References into Functions

Here, the authors determined crystal structures of AtBAG5 alone and in complex with Ca(2+)-free CaM. Structural and biochemical studies revealed that Ca(2+)-free CaM and Hsc70 bind AtBAG5 independently, whereas Ca(2+)-saturated CaM and Hsc70 bind AtBAG5 with negative cooperativity. PMID: 27539741
Data conclude that an HSC70-SGT1 chaperone complex is important for multiple plant environmental responses and that the evolutionarily conserved SGS domain of SGT1 is a key determinant of the HSC70-SGT1 association. PMID: 18065690
HSC70-1 is involved in development and abiotic stress responses in Arabidopsis. PMID: 19443614

Subcellular Location

Cytoplasm, cytosol. Nucleus.

Protein Families

Heat shock protein 70 (TC 1.A.33) family, DnaK subfamily

Tissue Specificity

Expressed at a substantial level during normal growth in root, stem, leaf and flower tissues, but not in siliques. Expressed in cotyledons, leaves, stems, vascular bundles, roots, stigmas and anthers.

Database Links

KEGG: ath:AT5G02500

STRING: 3702.AT5G02500.1

UniGene: At.23663

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HSP70-1 Antibody

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