Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MDM30 Polyclonal antibody

Uniprot No.

Q05930

Target Names

MDM30

Alternative Names

MDM30 antibody; YLR368W antibody; Mitochondrial distribution and morphology protein 30 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MDM30 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes FZO1 and regulates the amount of FZO1. Regulatory factor for the mitochondrial fusion machinery. Required for mitochondrial DNA maintenance.

Gene References into Functions

Mdm30-Ubp2-Rsp5 crosstalk regulates mitochondrial fusion by coordinating an intricate balance between Fzo1 turnover and the status of fatty acids saturation. PMID: 28607491
Mdm30 promotes mRNA export by lowering Sub2's stability and consequently enhancing Yra1 recruitment. PMID: 24327750
Findings suggest a sequence of events in early mitochondrial fusion where Fzo1 GTPase-domain-dependent tethering leads to recruitment of SCF(Mdm30) and ubiquitin-mediated degradation of Fzo1, which facilitates mitochondrial fusion. PMID: 21502136
Mdm30-dependent degradation of Fzo1 completes Fzo1 function in mitochondrial outer membrane fusion. PMID: 21385840
These results suggest that the Dsg1-mediated efficient transcription process of GAL genes may depend on the interaction status between Gal4p and Gal80p. PMID: 20135317
Destruction of transcriptionally active Gal4 depends on an F box protein called Dsg1/Mdm30. PMID: 15797387
Mitochondria-associated F-box proteins Mfb1 and Mdm30 are key components of a complex machinery that regulates mitochondrial dynamics throughout yeast's entire life cycle. PMID: 16790496
We identified the mitochondrial outer membrane protein Mdm34p as a target of Mdm30p. PMID: 18775025
Mdm30p selectively controls mRNA export independently of mitochondrial fusion, revealing a novel function of an F-box protein in mRNA export. PMID: 19376128

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Subcellular Location

Cytoplasm. Mitochondrion.

Database Links

KEGG: sce:YLR368W

STRING: 4932.YLR368W

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MDM30 Antibody

Product Details

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Target Background