MEC3 Antibody

Datasheet

Code	CSB-PA104412XA01SVG
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MEC3 Polyclonal antibody

Uniprot No.

Q02574

Target Names

MEC3

Alternative Names

MEC3 antibody; PIP3 antibody; PSO9 antibody; YLR288C antibody; L8003.15DNA damage checkpoint control protein MEC3 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MEC3 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA.

Gene References into Functions

a Ddc1-Mec3-Rad17 sliding clamp has a role in regulating histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast PMID: 24573675
Overexpression of MEC3 in a DDC1Delta strain shows no rescue of DNA damage sensitivity. PMID: 16137930
the 9-1-1 clamp, made of Ddc1, Rad17, and Mec3, may physically regulate Polzeta-dependent mutagenesis by controlling the access of Polzeta to damaged DNA PMID: 16169844
a mutant allele of the DNA damage checkpoint gene MEC3 is in Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae PMID: 16202664
Control of telomeric recombination by Mec3. PMID: 17202155

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Subcellular Location

Nucleus.

Protein Families

MEC3 family

Database Links

KEGG: sce:YLR288C

STRING: 4932.YLR288C

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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