MED29 Antibody

Code CSB-PA885752XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MED29 Polyclonal antibody
Uniprot No.
Target Names
MED29
Alternative Names
MED29 antibody; IXL antibody; Mediator of RNA polymerase II transcription subunit 29 antibody; Intersex-like protein antibody; Mediator complex subunit 29 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) MED29 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Gene References into Functions
  1. A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex PMID: 14576168
  2. Overexpression of IXL in COS-7 cells inhibits the transcriptional activities of SRE and AP-1, suggesting that the IXL protein may act as a transcriptional suppressor in mitogen-activated protein kinase signaling pathway to mediate cellular functions. PMID: 15555573
  3. IXL is required for cancer cell survival in 19q13-amplified tumors. PMID: 17332321
  4. IXL is a subunit of the mammalian Mediator complex. PMID: 14576168
Subcellular Location
Nucleus.
Protein Families
Mediator complex subunit 29 family
Tissue Specificity
Widely expressed in embryo and adult.
Database Links

HGNC: 23074

OMIM: 612914

KEGG: hsa:55588

STRING: 9606.ENSP00000314343

UniGene: Hs.611541

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