mes-2 Antibody

Datasheet

Code	CSB-PA515708XA01CXY
Size	US$299
Image	Western Blot Positive WB detected in: recombinant protein All lanes:mes-2 Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 30.6 kDa Observed band size: 32 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans mes-2 Antibody Polyclonal antibody

Uniprot No.

O17514

Target Names

mes-2 Antibody

Alternative Names

Histone-lysine N-methyltransferase mes-2 (EC 2.1.1.43) (E(z) homolog) (Maternal-effect sterile protein 2) mes-2 R06A4.7

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans mes-2 protein (281-525aa)

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Polycomb group (PcG) protein. Catalytic subunit of a the mes-2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. In association with the nfya-1-NF-Y complex, may play a role in repressing the expression of the homeobox protein egl-5 in tissues such as the head. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells. Required for small-RNA-induced H3K27 trimethylation. Involved in the negative regulation of lifespan in a germline-independent fashion.

Gene References into Functions

mes-2 mutants suppress mab-3. PMID: 12791262
mes-2 represses Hox expression, causing anteroposterior transformations and disrupts Hox-dependent neuroblast migration. PMID: 12791273
The SET domain of MES-2 functions as a histone h3 methyltransferase in X chromosome inactivation. PMID: 15380065
mes-2 orchestrates large-scale changes in chromatin organization and gene expression to promote the timely loss of developmental plasticity. PMID: 19460346

Subcellular Location

Nucleus.

Protein Families

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily

Tissue Specificity

In adults, it is predominantly expressed in the germline, and weakly expressed in intestinal cells. Expressed in the hypoderm.

Database Links

KEGG: cel:CELE_R06A4.7

STRING: 6239.R06A4.7

UniGene: Cel.19654

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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mes-2 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background