METTL13 Antibody

Code CSB-PA847648XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) METTL13 Polyclonal antibody
Uniprot No.
Target Names
METTL13
Alternative Names
5630401D24Rik antibody; CGI-01 antibody; MET13_HUMAN antibody; Methyltransferase-like protein 13 antibody; Mettl13 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) METTL13 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'. Has no activity towards core histones H2A, H2B, H3 and H4. Negatively regulates cell proliferation at G1/S transition via transcriptional suppression of cell cycle regulatory genes such as CDK4 and CDK6.
Gene References into Functions
  1. METTL13 gene rs2232825 locus or a linked functional locus may modulate the vulnerability to development of postpartum psychosis. PMID: 28483099
  2. Single nucleotide polymorphism association study demonstrated association METTL13 on chromosome 1 with Postpartum Depression.METTL13 is putatively involved with methyltransferase activity, which has been shown to play a role in estrogen receptor-induced gene transcription. PMID: 29082433
  3. These integrated efforts have identified METTL13 as a tumor suppressor and might provide promising approaches for bladder cancer treatment and prevention. PMID: 26763933
Subcellular Location
Cytoplasm. Nucleus. Mitochondrion.
Protein Families
Methyltransferase superfamily
Database Links

HGNC: 24248

KEGG: hsa:51603

STRING: 9606.ENSP00000354920

UniGene: Hs.494705

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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