Mgmt Antibody

1. This study shows that when cell death and cell cycle arrest pathways are inhibited, p53 can still mediate MGMT-dependent repair, to promote cell survival upon DNA damage. PMID: 28753207
2. Snell, GHKRO, and PAPPA-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1). PMID: 27618784
3. This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG, as a key node in determining a carcinogenic threshold. PMID: 26243310
4. Findings suggest that O6-methylguanine-DNA methyltransferase (MGMT)-mediated temozolomide resistance is associated with increased histone acetylation. PMID: 22675172
5. Loss of MGMT expression and high Ezrin protein expression leads to esophageal cancer. PMID: 22196440
6. Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis. PMID: 20732909
7. Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. PMID: 13679151
8. Repression of MGMT is associated with precancerous conditions in hyperplastic mucosa adjacent to colon cancer PMID: 15354418
9. GAMT and AGAT mRNA are up-regulated 5.4- and 1.9-fold respectively in adult mdx muscle compared to C57 PMID: 17588756
10. In vivo selection of MD9-P140K-transduced BM cells was more efficient following submyeloablative than myeloablative therapy. PMID: 18279716
11. MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). PMID: 18281247
12. Mgmt suppresses intestinal cancer associated with exogenous alkylating agents. PMID: 19029948
13. IFN-beta appears to sensitize neuroblastoma cells to the cytotoxic effects of temozolomide through attenuation of MGMT expression PMID: 19056675
14. In the fetal brain, mRNA expression of AGAT increased steadily across the second half of pregnancy. In the fetal kidney and liver, AGAT mRNA and protein expression were also relatively low until 34-37 days gestation. PMID: 19570237

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KEGG: mmu:17314

STRING: 10090.ENSMUSP00000080224

UniGene: Mm.440219