Mical Antibody

Datasheet

Code	CSB-PA772974XA01DLU
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Mical Polyclonal antibody

Uniprot No.

Q86BA1

Target Names

Mical

Alternative Names

Mical antibody; CG33208[F-actin]-monooxygenase Mical antibody; EC 1.14.13.225 antibody; Molecule interacting with CasL protein homolog antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Mical protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits at 'Met-44' and 'Met-47' through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament disassembly and prevent repolymerization. Plays a key role in semaphorin-plexin repulsive axon guidance and cell morphological changes, probably via its ability to modify and regulate actin.

Gene References into Functions

Results identify Mical-like as a novel regulator of synaptic growth and FasII endocytic recycling. PMID: 27770767
Mical oxidizes actin stereospecifically to generate actin Met-44-R-sulfoxide. PMID: 24212093
Mical is both necessary and sufficient for semaphorin-plexin-mediated F-actin reorganization in vivo PMID: 20148037
MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. PMID: 12110185
Transgenic expression of interfering RNA molecules demonstrates that MICAL is required in muscles for the higher order arrangement of myofilaments. PMID: 17350233

Hide All

Subcellular Location

Cytoplasm.

Protein Families

Mical family

Tissue Specificity

Present in neuronal cell bodies, along axons, and in growth cones. Appears in the nervous system at stage 13 and labels motor and CNS projections, and at later embryonic stages, it is present on axons that make up all motor axon pathways: the intersegment

Database Links

KEGG: dme:Dmel_CG33208

STRING: 7227.FBpp0297564

UniGene: Dm.32089

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

TWIK2 channel mediates inflammation, study finds SWISS-PROT: When and How to Use It Protein Acetylation: An Important Post-translational Modification in Eukaryotic Cells Neuronal Markers and Neurodegenerative Diseases GPC3: The Next-Promising Target in Cancer Immunotherapy Non-Hodgkin's Lymphoma, One of Common Heterogeneous Malignant Tumors Information You Must Know about KCNN4 The Overview of One Category of Important Cell Receptors: Receptor Tyrosine Kinases TNFRSF9: A Potent Immune-Stimulator in Cancer Cross-reactivity of Antibody: Beneficial or Harmful? TNFR1: A Multifaceted Molecule in Cancer, Another Promising Therapeutic Target for COVID-19 Approaches to Determinate Protein Concentration DLL3: A New Molecular Target in Cancer DNA Damage and Repair TFPI: a Natural Anticoagulant Protein, Future Therapies for Hemophilia Proteolysis Targeting Chimera (PROTAC): A "Revolutionary" Technology in Small Molecule Drug Discovery! CLDN6: A "New Favorite" in Targeted Cancer Therapy after CLDN 18.2! DDR1: a Novel Member of the RTKs Family, a Potential Target for Tumor Therapy! TPBG/5T4: the Oncofetal Protein, an Appealing Target for ADC or Vaccine Therapeutics in Tumors! Intestinal Mucosal Barrier Bodyguard --ALPi Dual Role of TNFRSF14 in Immunology How Do You Get Exosomes? Cell Differentiation Determines the Fate of Cells CD73, What a Powerful Therapy Target in Tumor Immune CAR-T Cell Therapy- An Useful Treatment To Cancer CLDN4: A Potential Prognostic Indicator and Therapeutic Target in Tumors！ What Are the Best Methods for Protein Purification? A Practical Guide CD19-The Most Popular Target with CAR T-Cell Therapy TFR1 (TFRC): a Stimulator of Fe Transport Affects Anemia, Neurodegenerative Disorders and Cancers! Categories over 10000! --Rare diseases that are no longer SLC7A11: a New Potential Therapeutic Target via Induced Ferroptosis in Tumors! Tuberculosis--A Resurgent Tag Antibodies, Your Good Partner in Protein Research How to Inquire and Utilize the Signal Pathway on KEGG Costimulatory/Coinhibitory: Is B7-H3 An Enemy or A Friend? The Overview of Recombinant Antibody Glial Fibrillary Acidic Protein - Astrocyte Specific Marker MYL9: a New Member of Myosin Motors, a Key Driver of Cancer Cell Dynamic Regulation? ZG16B: A New Tumor Biomarker Offers Important Insights for Drug Development in Pancreatic Cancer! New Mechanism, NRP1 Enhances the Ability of SARS-CoV-2 Infection Oct4 -- The Gatekeeper of Pluripotency of Embryonic Stem Cells Leukemia, Why is it So Common? CEACAM8: a Member of CEA Family, Emerging as a Vital Player in Gynaecological or Gastrointestinal Cancer Research! Biological Activity of Proteins The Overview of Cell Viability Bladder Cancer: Insights into Molecular Biology,Signaling Pathways, and Biomarkers CD147, a New Target of SARS-CoV-2 Invasion The Application of IHC in Pathological Diagnosis The difference between primary antibody and secondary antibody A "trembling" Parkinson's Disease The Overview of Coagulation Understanding of Serum Albumin VSIG4: a Prominent B7 Family Costimulatory Molecule or Complement Receptor in Cancers and Inflammatory Diseases! Monoclonal Antibody Drugs Overview SLC39A6/ZIP6: a Key Member of Zinc Transporters, a Novel Targeting Antigen of ADC! What You Have To Know about Lung Cancer Protein Kinases Overview: Definition, Types, Function, Activation Mechanism, etc. Exploring Neurodegeneration: A Comprehensive Guide for Researchers Tools You Need For Fundamental Research What Powerful Model Organism Databases How Does Histone Modification Affect Gene Expression? Unraveling the Dynamic World of Histone Modifications: Implications in Gene Regulation and Disease Pathogenesis About Thyroid Tumor, This Information You Must Know! What Essential Biological Knowledge is Needed for Hepatocellular Carcinoma Research? ELISA vs. Multiplex Immunoassays: Why ELISA Remains the Gold Standard among Immunoassays CD70 (CD27L/TNFSF7): a TNF Receptor Member, a “Star” Target for Clinical Research in Systemic Lupus Erythematosus (SLE), Arthritis, and Tumors! Diabetes: What You Need to Know Before Starting Research? Epitope Tags Overview Tetraspanin CD81: a Key Receptor for Hepatitis C Virus (HCV), an Established Exosome Marker, a Promising Target for Antiviral or Antitumor Research! Does TNF Superfamily Inhibit Cancer or Promote Its Development? An Overview of CD226 and Its Promising Role in Cancer Immunotherapy TROP2, An Important Target for Cancer Research OMA1-A Potential Cancer Therapy Target Latest Changes in Journal Impact Factor TM4SF1: a Member of the Transmembrane-4-Superfamily (L6), a New Vascular Therapeutic Target? Surface Markers of Natural Killer Cells What Is an Antibody? Mucin-17/MUC17: An Unexpected Target for Tumor Immune Therapy, Notably Gastric Cancer! ANGPT2 (Ang-2): the First Bispecific Antibody for Eye Vision Loss Therapy, a Novel Target for Tumor Angiogenesis! Protein Tags: A Comprehensive Overview ALPG: a Germ Cell-Associated Alkaline Phosphatase (ALP), a Highly Specific Cell Surface Antigen in Cancers! CUSABIO's Five Expression Systems Serotransferrin/TF: a Major Transferrin in Plasma, a Novel TF-Modified Nanoparticle for Tumor-Targeting Research! Myosin Regulatory Light Chains (MYL12A and MYL12B): the New Functional Ligands for CD69, Potential Targets for Cardiac Disease or Tumors Research? Do You Really Know Neurons and Glia Cells in Nerve System? Apoptosis mediated by mitochondria Apoptosis mediated by death receptor Inhibition of ASCT2 combats cancer in vitro and in vivo Aesthetic Appreciation of Apoptosis Signal Pathway Get An Overview of His-Tag PD-1/PD-L1, What a Powerful Immune Checkpoint EphA3-A Regulator of Cell Adhesion and Migration Cadherin-17 (CDH17): A Viable Target in Bispecific Antibodies or CAR-T Therapy to Fight Many Gastrointestinal Cancers! Itaconate is a negative regulator of inflammation The Overview of Interferon Tumor markers The Overview of Organelles How to Choose an Antibody for Scientific Research? TTR: an Important Protein of Amyloidosis, Novel Therapies are Upcoming for Rare Diseases ATTR-CM and ATTR-PN! The overview of Wnt signaling pathway PI3K-Akt Signaling Pathway and Cancer Double-Edged Sword: TGF-β CCR9: A Member of the Chemokine Receptor Family, an Emerging Target for Numerous Tumor Researches! Chemokine Receptor CCR6: the Specific Receptor for CCL20, a Potential Target for Drug Research in Inflammatory Diseases and Gastrointestinal Cancer! CEACAM6: a Potent CEA Family Molecule, a New Tumor Marker or Anti-Cancer Target! IL2RA (CD25): A Specific Marker of Tregs Functions as Both Immune Modulators and Targeted Agents in Various Diseases! Bispecific Antibody Overview: From Definition to Application The Review of Post-translational Modifications ENPP3 (CD203c): An Extracellular Enzyme, a Regulator for Nucleotide and Energy, an Indicator for Allergies, an Effective Target for RCC Therapy! SSTR2: A Prominent Target in SSTR Family, Offers a More Precise Therapy in Neuroendocrine Tumors (NET) CADM1: an Immunoglobulin Superfamily Molecule, a New Tumor Suppressor Gene! Oncostatin M (OSM): A Member of IL-6 Cytokine Family, An Underestimated Player in Future Targeted Therapies? In Vivo vs. In Vitro: Choosing the Right Experimental Model for Your Research Exploring Protein-Protein Interactions: A Comprehensive Guide to Understanding and Utilizing It IL-6: an Important Participant in the Inflammatory Cascade, One of the Most Functional Cytokines in Various Diseases Research! What Are the Best Antibody Purification Methods for Your Research Needs? Verified vs. Unverified Recombinant Proteins: Making the Right Choice for Your Research What Bacterial Antigens Are Used in Vaccines? What Is Compartment Modelling in Pharmacokinetics? ACVR2A and ACVR2B as Key Targets for Muscle Growth, Weight Loss, PHA in Drug Research！ A Comprehensive Guide to Monoclonal Antibody Production How do we dissolve BSA? Antigen Retrieval: Uncovering Antigen Masking to Improve Immunohistochemistry Results How the Tumor Microenvironment Fuels Cancer's Deadly Evolution Decoding Recombinant Protein Expression: Strategic Solutions & Practical Insights CCL17: A Chemokine with Multiple Biological Functions Colony Stimulating Factor 1 (CSF1): Its Key Role in Diseases and New Progress in Targeted Therapy MICB: a key molecule that bridges cellular stress and immune responses LYPD3: An Emerging Star in Solid Tumor Therapy Targeting the "Hidden Target" ROR1: A Breakthrough for Broad-Spectrum Cancer Therapy? SEZ6: A New Therapeutic Target for Neuroendocrine Tumors with Multiple ADCs in Clinical Development Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Mical Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background