mig-13 Antibody

Code CSB-PA794243XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans mig-13 Polyclonal antibody
Uniprot No.
Target Names
mig-13
Alternative Names
mig-13 antibody; F43C9.4Abnormal cell migration protein 13 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans mig-13 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Probable receptor that acts as an upstream signaling protein to promote the guidance, migration and positioning of the right Q neuroblast (QR) and its descendants along the anteroposterior body axis, and also the anterior migration of BDU interneurons during larval development. Associates with and recruits the downstream components tyrosine kinase abl-1 and the tyrosine kinase adapter protein sem-5 to the leading edge of migrating Q neuroblasts and their descendants to activate signaling through the two parallel wve-1 and wsp-1 pathways, respectively, and direct migration along the anteroposterior body axis. Involved in cytoskeleton dynamics regulating the organization of the actin cytoskeleton at the leading edge of migrating cells to ensure correct Q cell polarity and promote migration. Role in cytoskeleton organization may be by activation of the wve-1 and wsp-1 pathways which recruit the Arp2/3 complex to the leading edge of migrating cells. Plays a role in regulating the asymmetric distribution of the actin cytoskeleton-binding protein cor-1 in Q neuroblasts which is required for the anterior migration of QR neuroblasts.
Gene References into Functions
  1. MIG-13, an evolutionarily conserved transmembrane protein, cell-autonomously regulates the asymmetric distribution of the actin cytoskeleton in the leading migratory edge. PMID: 23784779
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, axon. Cell projection, dendrite.
Tissue Specificity
Expressed in pharyngeal-intestinal valve cells and ventral cord neurons.
Database Links

KEGG: cel:CELE_F43C9.4

STRING: 6239.F43C9.4a

UniGene: Cel.19567

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