Mipp1 Antibody

Code CSB-PA827026XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Mipp1 Polyclonal antibody
Uniprot No.
Target Names
Mipp1
Alternative Names
Mipp1 antibody; CG4123 antibody; Multiple inositol polyphosphate phosphatase 1 antibody; EC 3.1.3.62 antibody; 2,3-bisphosphoglycerate 3-phosphatase antibody; 2,3-BPG phosphatase antibody; EC 3.1.3.80 antibody; Inositol antibody; 1,3,4,5)-tetrakisphosphate 3-phosphatase antibody; Ins(1,3,4,5)P(4) 3-phosphatase antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Mipp1 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. Has a role in embryonic tracheal development where it localizes to the leading edge of actively migrating branches. In these leading cells, enhances formation and/or maintenance of filopodia which may drive branch migration and elongation by cell-cell intercalation. The function in tracheal morphogenesis is dependent on its inositol polyphosphate phosphatase activity.
Gene References into Functions
  1. Mipp1 facilitates formation and/or stabilization of filopodia in leading cells through its extracellular activity PMID: 26628373
Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Basolateral cell membrane. Cell projection, filopodium. Cell junction.
Protein Families
Histidine acid phosphatase family, MINPP1 subfamily
Database Links

KEGG: dme:Dmel_CG4123

STRING: 7227.FBpp0075156

UniGene: Dm.2760

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