Mip Antibody

Datasheet

Code	CSB-PA892903XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Mip Polyclonal antibody

Uniprot No.

Q9VVF7

Target Names

Mip

Alternative Names

Mip antibody; CG6456 antibody; Allatostatins MIP antibody; B-type Allostatin preprohormone antibody; Myoinhibitory-like protein) [Cleaved into: Drostatin-B1 antibody; MIP-1); Drostatin-B2 antibody; MIP-2); Drostatin-B3 antibody; MIP-3); Drostatin-B4 antibody; MIP-4); Drostatin-B5 antibody; MIP-5)] antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Mip protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Ligand for the sex peptide receptor (SPR). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat. May also have a regulatory role in gut motility.

Gene References into Functions

Mip neuropeptides appear to promote mating receptivity both in virgins and mated females, although it is dispensable for normal mating in virgin females. PMID: 29158481
MIP signaling in chemosensory neurons is an instructive signal adjusting female choice behavior to reproductive state. PMID: 27145127
MIP encodes anorexigenic brain signaling that determines body weight.MIP produces satiety responses independently of sex peptide receptor.MIP modulates behavioral responses to olfactory and gustatory cues of food. PMID: 26948873
Our results illuminate how cell type specific versions of the Mip/dREAM complex and the general transcription machinery cooperate to drive selective gene activation during differentiation in stem cell lineages. PMID: 26624996
released centrally before and during night-time sleep, when the sleep drive is elevated PMID: 25333796

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Subcellular Location

Secreted.

Tissue Specificity

In larvae, strongly expressed in the midgut region before and in between the copper cells, and in a group of cells in the posterior part of the larval midgut. Expressed in the neurons of many areas including the subesophageal ganglion/tritocerebrum (SOG),

Database Links

KEGG: dme:Dmel_CG6456

STRING: 7227.FBpp0075003

UniGene: Dm.4361

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Mip Antibody

Product Details

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Customer Reviews and Q&A

Target Background