p38b Antibody

Code CSB-PA523994XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) p38b Polyclonal antibody
Uniprot No.
Target Names
p38b
Alternative Names
p38b antibody; CG7393 antibody; Mitogen-activated protein kinase p38b antibody; MAP kinase p38b antibody; MAPK p38b antibody; EC 2.7.11.24 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) p38b protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Kinase involved in dpp signal transduction pathway in the process of wing morphogenesis when the levels of dpp are enhanced or inhibited. May down-regulate insect immunity gene expression after prolonged infection.
Gene References into Functions
  1. Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways. PMID: 25144774
  2. data suggest that p38Kb may affect circadian locomotor rhythms through the regulation of multiple downstream pathways PMID: 25403440
  3. The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis. PMID: 23438069
  4. found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles PMID: 22801366
  5. Loss of p38 MAPK causes early lethality and precipitates age-related motor dysfunction and stress sensitivity. PMID: 22014527
  6. The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection. PMID: 21076039
  7. p38b MAPK plays a crucial role in the balance between intestinal stem cell proliferation and proper differentiation in the adult Drosophila midgut. PMID: 20157545

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Subcellular Location
Nucleus.
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
Tissue Specificity
At mid-embryogenesis, highest expression is seen in developing anterior and posterior midguts. Almost ubiquitous expression throughout all development.
Database Links

KEGG: dme:Dmel_CG7393

STRING: 7227.FBpp0080111

UniGene: Dm.2953

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