MKP1 Antibody

Code CSB-PA903524XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) MKP1 Polyclonal antibody
Uniprot No.
Target Names
MKP1
Alternative Names
MKP1 antibody; At3g55270 antibody; T26I12.150 antibody; Protein-tyrosine-phosphatase MKP1 antibody; EC 3.1.3.48 antibody; Mitogen-activated protein kinase phosphatase 1 antibody; AtMKP1 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana MKP1 protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Protein-tyrosine-phosphatase that acts as a negative regulator of MPK6 and MPK3 signaling by dephosphorylating and repressing MPK6 and MPK3. Modulates defense response by repressing salicylic acid (SA) production, camalexin biosynthesis and SNC1-mediated responses. Acts as a negative regulator of MPK6-mediated pathogen-associated molecular pattern (PAMP) responses, including MPK6 and MPK3 activation, accumulation of extracellular reactive oxygen species and inhibition of seedling growth. Involved in UV-B stress tolerance. May be involved in salt and genotoxic stress responses.
Gene References into Functions
  1. These results provide insight into the roles of phosphorylation in the regulation of MKP1 during pathogen-associated molecular pattern signaling and resistance to bacteria. PMID: 29070514
  2. MKP1 role in ultraviolet induced stomatal closure PMID: 27837091
  3. These results identify MKP1 as a protein dually targeted to cytosol and peroxisomes. PMID: 25817413
  4. mkp1, a mutant that is more resistant to bacterial infection, induces decreased levels of type III secretion system effectors in Pseudomonas syringae. PMID: 24753604
  5. ATR and MKP1 play distinct roles in response to UV-B stress.MKP1-regulated and ATR-mediated DNA damage pathways operate independently of each other. PMID: 23237049
  6. MKP1 is a phosphoprotein in vivo that MKP1 accumulates in response to UV-B stress PMID: 23188831
  7. Regulation of MAPK phosphatase 1 (AtMKP1) by calmodulin in Arabidopsis. PMID: 18579522

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Subcellular Location
Cytoplasm, cytosol.
Database Links

KEGG: ath:AT3G55270

STRING: 3702.AT3G55270.1

UniGene: At.21664

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