mats Antibody

Code CSB-PA842576XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) mats Polyclonal antibody
Uniprot No.
Target Names
mats
Alternative Names
mats antibody; CG13852 antibody; MOB kinase activator-like 1 antibody; Mob as tumor suppressor protein 1 antibody; Dmob1 antibody; Mps one binder kinase activator-like 1 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) mats protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Coactivator of Warts (Wts) kinase in the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki)oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Mats is essential for early development and is required for proper chromosomal segregation in developing embryos.
Gene References into Functions
  1. Mob as tumor suppressor is regulated by bantam microRNA through a feedback loop for tissue growth control PMID: 24016667
  2. These results support a model in which the plasma membrane is an important site of action for Mats tumor suppressor to control tissue growth and organ size. PMID: 19913529
  3. described growth inhibitory functions for a Mob superfamily protein, termed Mats; loss of Mats function results in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth [Mats] PMID: 15766530
  4. mats regulation in development was studied. PMID: 18472003
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytosol. Cell membrane. Note=Colocalizes with wts and cyclin E at the centrosome.
Protein Families
MOB1/phocein family
Tissue Specificity
Ubiquitously expressed at low levels in developing tissues (at protein level).
Database Links

KEGG: dme:Dmel_CG13852

STRING: 7227.FBpp0083624

UniGene: Dm.3572

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