Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans oma-1 Polyclonal antibody

Uniprot No.

G5EC86

Target Names

oma-1

Alternative Names

oma-1 antibody; moe-1 antibody; C09G9.6 antibody; CCCH-type zinc finger protein oma-1 antibody; Maturation oocyte expansion protein 1 antibody; Oocyte maturation defective protein 1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans oma-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif-1 to negatively regulate their translation. By suppressing the translation of the E3 ligase zif-1, may in turn play a role in the stabilization of zif-1 targets such as the maternal transcriptional repressor protein pie-1. Following fertilization, sequesters the transcription initiation factor, taf-4, in the cytoplasm, which prevents its nuclear localization and thus allows for transcriptional suppression in early embryos, but not in oocytes. Also, together with oma-2, is involved in P-granule distribution during embryonic development.

Gene References into Functions

OMA-1 promotes expression of spn-4 and meg-1during oocyte meiotic maturation and the oocyte-to-embryo transition. PMID: 28576864
interplay between OMA-1 and other factors for overlapping binding sites helps to coordinate the transition from oocyte to embryo PMID: 24014033
A gain-of-function mutation in this gene required for oocyte maturation results in delayed degradation of maternal proteins and embryonic lethality. PMID: 12781695
OMA-1 is identified as an in vivo substrate for dual specificity protein (DYRK) family kinase MBK-2. PMID: 16289132

Subcellular Location

Cytoplasm. Cytoplasmic granule. Nucleus.

Tissue Specificity

Exclusively expressed in the hermaphrodite gonad. Expressed prior to oocyte division. Widely distributed throughout gonadal oocytes from the mitotic stage to the developing diakinesis stage. Expressed in sperm.

Database Links

KEGG: cel:CELE_C09G9.6

STRING: 6239.C09G9.6.1

UniGene: Cel.38696

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oma-1 Antibody

Product Details

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Target Background