Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) MOM1 Polyclonal antibody

Uniprot No.

Q9M658

Target Names

MOM1

Alternative Names

MOM1 antibody; MOM antibody; At1g08060 antibody; T6D22.14 antibody; Helicase protein MOM1 antibody; EC 3.6.4.- antibody; Protein MAINTENANCE OF METHYLATION antibody; Protein MORPHEUS MOLECULE 1 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana MOM1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Required for the heritable maintenance of transcriptional gene silencing (TGS) in heterochromatin, and particularly in the intermediate bivalent heterochromatin, characterized by an unsual methylation pattern consisting in hypermethylated DNA and histone H3 'Lys-4' methylation (H3K4me) together with depletion of histone H3 'Lys-9' methylation (H3K9me), in a chromatin methylation-independent manner, in a non-CG methylation context. May play a role in the RNA polymerase IV/V (Pol-IV/V)-mediated RNA-directed DNA methylation (RdDM) leading to TGS (also called siRNA-mediated TGS pathway), probably by modulating small interfering RNA (siRNA) accumulation. Especially involved in the gene silencing of the transcriptionally silent information region (TSI), 5S ribosomal RNA genes (localized in the pericentromeric heterochromatin of chromosomes 3, 4, and 5) and of 180-bp satellite repeats and 106B long terminal repeat (LTR)-like repeats of the chromocenters. Prevents the aberrant mRNA transcriptional read-through.

Gene References into Functions

synergistic transcriptional regulation in the mom1/atmorc6 double mutant, indicating that these epigenetic regulators act mainly in different silencing pathways, both independently of DNA methylation PMID: 24799676
These results reveal a surprising separation of epigenetic activities that enable the single, large MOM1 protein to coordinate cooperating mechanisms of epigenetic regulation PMID: 22346760
the degree of contribution of MOM1 to maintenance of the silent states varies in different loci, and other silencing machineries, including those in the RNA-directed DNA methylation pathway, interact genetically with MOM1 PMID: 21464619
MOM1 plays a role in preventing aberrant RNA transcriptional read-through. PMID: 20826701
Crystals of Morpheus' molecule 1 belonged to the trigonal space group P3(1)21 (or P3(2)21), with unit-cell parameters a=85.64, c=292.74 A. Structure determination is ongoing PMID: 20693667
Pol-V is required for MOM1-mediated suppression of transcription at a subset of its chromosomal targets. PMID: 19910926
Less than 13% of MOM1 sequence is necessary and sufficient for its transcriptional gene silencing function. PMID: 18725928

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Subcellular Location

Nucleus.

Database Links

KEGG: ath:AT1G08060

STRING: 3702.AT1G08060.1

UniGene: At.20225

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