morc-1 Antibody

Code CSB-PA574811XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans morc-1 Polyclonal antibody
Uniprot No.
Target Names
morc-1
Alternative Names
morc-1 antibody; ZC155.3 antibody; Protein morc-1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans morc-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Binds non-specifically to DNA and forms static foci which grow by recruiting other morc-1 molecules, and thereby stimulates conformational changes and compaction of DNA, which appears to be enhanced by ATP-binding, but does not require ATP activity. Preferentially binds to long DNAs. Compacts and entraps segments of DNA by sequentially forming loops along the DNA, beginning at the free ends of single- and double-tethered DNA. Does not extrude the DNA loops on compacted double-tethered DNA. Involved in gene silencing. Plays a role in germline RNA interference (RNAi), and in particular, the silencing of endogenous small interfering RNA (endo-siRNA) target genes. May play a role in heterochromatin localization and condensation, and the siRNAi-directed trimethylation of 'Lys-9' of histone H3 in hermaphrodite X chromosomes. Promotes transgenerational epigenetic inheritance and germline immortality.
Gene References into Functions
  1. morc-1 is essential for transgenerational fertility and acts as an effector of endo-siRNAs. PMID: 28535375
Subcellular Location
Nucleus. Nucleus, nuclear body.
Tissue Specificity
Expressed in germline and somatic cells.
Database Links

KEGG: cel:CELE_ZC155.3

STRING: 6239.ZC155.3

UniGene: Cel.5348

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