rtp Antibody

Code CSB-PA254754XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) rtp Polyclonal antibody
Uniprot No.
Target Names
rtp
Alternative Names
rtp antibody; morn4 antibody; uta antibody; CG10233 antibody; MORN repeat-containing protein 4 homolog antibody; Retinophilin antibody; undertaker antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) rtp protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. Organizes rhabdomeric components to suppress random activation of the phototransduction cascade and thus increases the signaling fidelity of dark-adapted photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina.
Gene References into Functions
  1. A mutation is characterized which affects an evolutionarilyy conserved protein, retinophilin (Retin), expressed in the phototransducing compartment of photoreceptor cells. PMID: 20739554
  2. We propose that RTP is a light-regulated phosphoprotein that organizes rhabdomeric components to suppress random activation of the phototransduction cascade and thus increases the signaling fidelity of dark-adapted photoreceptors. PMID: 20107052
  3. retinophilin is expressed in fly photoreceptor cells PMID: 17285308
Subcellular Location
Membrane.
Tissue Specificity
Retina. Expressed primarily in the phototransducing compartment of photoreceptor cells, the rhabdomeres and its expression is dependent on ninaC protein (at protein level).
Database Links

KEGG: dme:Dmel_CG10233

STRING: 7227.FBpp0078467

UniGene: Dm.9865

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