Mpdz Antibody

1. This work provides a relevant hydrocephalus mouse model and demonstrates that Mpdz is essential to maintain integrity of the ependyma. PMID: 28500065
2. Variants of the multiple PDZ domain gene Mpdz may contribute to the observed inter-strain variability in opioid tolerance and opioid-induced hyperalgesia by virtue of changes in the level of their expression. PMID: 27129385
3. MUPP1-PDZ4 domain contained three alpha-helices and six beta-strands in the core. The GLGI motif, L562/A564 on the beta-strand B, and H605/V608/L612 on the alpha-helix B formed a PDZ binding pocket which could bind to the C-terminal of the binding partners. PMID: 25662616
4. Increased MPDZ expression decreased the severity of ethanol withdrawal, while decreased MPDZ expression increased ethanol withdrawal severity. Decreased MPDZ expression was associated with increased voluntary ethanol consumption. PMID: 24118405
5. neurexin 1 interaction with multi-PDZ domain protein MUPP1 PMID: 25036961
6. Our results confirm that Mpdz is a quantitative trait gene for alcohol withdrawal and demonstrate that its expression in the caudolateral substantia nigra pars reticulata is crucially involved in risk for alcohol withdrawal. PMID: 25109596
7. regulates odor responses and activation kinetics of olfactory sensory neurons PMID: 24652834
8. despite their terminal sequence diversity all three GABA transporter PDZ motifs interacted with MUPP1 domain 7 PMID: 25305483
9. Cadm1 specifically interacts with Mupp1, and may form a ternary complex with Mupp1-GABBR2 in the cerebellum. PMID: 22994563
10. CaMKIIalpha interacts with MUPP1 in spermatozoa to prevents spontaneous acrosomal exocytosis. PMID: 19934217
11. 5-HT2C R interaction with MUPP1 is dynamically regulated by phosphorylation at Ser458 PMID: 12682077
12. MUPP1 protein expression is co-localized with 5-HT(2A) or 5-HT(2C) receptor expression in all regions of the mouse brain, including the choroid plexus where 5-HT(2C) receptors are highly enriched. PMID: 12706259
13. Mpdz may have pleiotropic effects on multiple seizure phenotypes, including seizures associated with withdrawal from two classes of central nervous system (CNS) depressants and sensitivity to specific chemiconvulsants. PMID: 14960011
14. This study identified an addiction-relevant quantitative trait gene, Mpdz. and provide a framework to define the protein interactions and neural circuit by which this multiple PDZ domain protein affects drug dependence, withdrawal and relapse. PMID: 15208631
15. this scaffolding protein, which comprises 13 different PDZ domains, is expressed in mouse testis. Immunoreactivity is concentrated within the acrosomal region of round as well as elongated mouse spermatozoa. PMID: 16452527
16. Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1. PMID: 17397395
17. This evidence points to a role of MUPP1 as a membrane raft-associated molecular organizer, suggesting that mammalian spermatozoa may use a scaffolding protein and membrane subdomains to organize components involved in the process of acrosomal exocytosis. PMID: 17894389
18. Linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1. PMID: 17939682
19. These data suggest that allelic variation in Mpdz, or a linked gene, influences SB242084- and baclofen-enhanced convulsions. PMID: 18262506
20. MUPP1 contributes to the maintenance of a tight epithelium in the medulla of the kidney under hypertonic stress by correctly localizing Cldn4 to the tight junctions PMID: 18840681
21. These results demonstrate MUPP1 at O/A gap junctions and Cx47-dependent targeting of connexins to the plasma membranes of oligodendrocyte somata. PMID: 18973575
22. Mpdz gene variations are known contributors of acute alcohol withdrawal severity and seizures in mice. PMID: 19175764
23. We have therefore elucidated the first building blocks of the putative 'olfactosome', brought together by the scaffolding protein MUPP1, a possible central nucleator of the olfactory response PMID: 19909339

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KEGG: mmu:17475

STRING: 10090.ENSMUSP00000099894

UniGene: Mm.153039