mre-11 Antibody

Code CSB-PA637565XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans mre-11 Polyclonal antibody
Uniprot No.
Target Names
mre-11
Alternative Names
mre-11 antibody; ZC302.1 antibody; Double-strand break repair protein mre-11 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans mre-11 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites.; Required for meiotic crossing over and chiasma formation. Pachytene morphology and homolog pairing are normal. Vital in long term for maintenance of reproductive capacity of subsequent generations.
Gene References into Functions
  1. A novel role for MRE-11 in the resection of double strand breaks in middle meiotic prophase I and in blocking nonhomologous end joining. PMID: 23671188
Subcellular Location
Nucleus.
Protein Families
MRE11/RAD32 family
Database Links

KEGG: cel:CELE_ZC302.1

STRING: 6239.ZC302.1.2

UniGene: Cel.2948

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