MRS2 Antibody

Code CSB-PA999936XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MRS2 Polyclonal antibody
Uniprot No.
Target Names
MRS2
Alternative Names
MRS2 antibody; YOR334W antibody; Magnesium transporter MRS2 antibody; mitochondrial antibody; RNA-splicing protein MRS2 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MRS2 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.
Gene References into Functions
  1. A functional and structural analysis of the regulatory domain of the eukaryotic divalent magnesium 2+ channel Mrs2 from yeast inner mitochondrial membrane is presented. PMID: 23999289
  2. inner mitochondrial domain of the Mrs2 from Saccharomyces cerevisae was overexpressed, purified and crystallized in two different crystal forms. The crystals diffracted X-rays to 1.83 and 4.16 A resolution, respectively. PMID: 20516593
  3. The Mrs2p is of central significance for the transport of Mg(2+) into mitochondria of S. cerevisiae. PMID: 20653776
  4. Data presented support the notion that effects of mutations in Mrs2p on group II intron splicing are a consequence of changes in steady-state mitochondrial Mg2+ concentrations. PMID: 16519685
Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
CorA metal ion transporter (MIT) (TC 1.A.35) family
Database Links

KEGG: sce:YOR334W

STRING: 4932.YOR334W

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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